Alignment of alleles: Atlantic cod (Gadus morhua) IGHV3S21

When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

Germline genomic sequences are needed to confirm if the nucleotide substitutions result from somatic mutations or correspond to allelic polymorphisms.

                                  1   2   3   4   5   6   7   8   9  10  11  12  13  14  15  16  17  18  19  20
                                 C   E   Q   L   T   Q   P   E   S       L   T   I   Q   P   G   Q   L   L   T
  AJ279386,IGHV3S21*01, 244     TGT GAA CAG CTT ACT CAG CCA GAG TCT ... CTG ACA ATT CAA CCT GGT CAA CTT CTG ACC
                                                                                                     P  
  AJ279387,IGHV3S21*02, 12      --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- -C- --- ---

                                                        ___________________CDR1-IMGT____________________
                                 21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40
                                 I   R   C   Q   V   F   Y   S   V   S   T   Y   A                       T   H
  AJ279386,IGHV3S21*01, 244     ATC CGC TGT CAG GTC TTT TAT TCT GTT AGT ACC TAC GCG ... ... ... ... ... ACA CAT
                                                     S  
  AJ279387,IGHV3S21*02, 12      --- --- --- --- --- -C- --- --- --- --- --- --- --- ... ... ... ... ... --- ---

                                                                                            _______________CDR2-
                                 41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60 
                                 W   I   R   Q   P   E   G   H   A   L   E   W   I   G   Y   I   Y   T   G   G
  AJ279386,IGHV3S21*01, 244     TGG ATC AGA CAA CCT GAA GGA CAT GCA CTG GAA TGG ATT GGA TAT ATT TAT ACC GGG GGC

  AJ279387,IGHV3S21*02, 12      --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                IMGT________________
                                 61  62  63  64  65  66  67  68  69  70  71  72  73  74  75  76  77  78  79  80
                                 K                   R   V   K   D   S   L   S       S   K   F   S   L   A   V
  AJ279386,IGHV3S21*01, 244     AAA ... ... ... ... AGA GTG AAA GAC TCC CTC AGT ... AGT AAA TTC AGT CTT GCC GTT

  AJ279387,IGHV3S21*02, 12      --- ... ... ... ... --- --- --- --- --- --- --- ... --- --- --- --- --- --- ---


                                 81  82  83  84  85  86  87  88  89  90  91  92  93  94  95  96  97  98  99 100
                                 D   S   S   T   K   T   V   T   L   Q   G   Q   N   M   Q   L   G   D   S   A
  AJ279386,IGHV3S21*01, 244     GAC AGC TCC ACT AAA ACA GTA ACT TTG CAA GGG CAA AAC ATG CAG CTT GGA GAC TCA GCT
                                                     I  
  AJ279387,IGHV3S21*02, 12      --- --- --- --- --- -T- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                                CDR3-IMGT
                                101 102 103 104 105 106 
                                 V   Y   Y   C   A   R
  AJ279386,IGHV3S21*01, 244     GTG TAT TAC TGT GCC AGA     #c

  AJ279387,IGHV3S21*02, 12      --- --- --- --- --- --G     #c
#c: rearranged cDNA

This alignment of allele is automatically generated by Mehdi Yousfi alignment of allele tool.

Created: 21/01/2002
Author: Nathalie Bosc